Research Articles
- Erin J. Pratt, Elena I. Mancera-Andrade, and Kevin L. Bicker. Synthesis and Characterization of Derivatives of the Antifungal Peptoid RMG8-8. ACS Omega. 2022. DOI: 10.1021/acsomega.2c04778
- R. Madison Green and Kevin L. Bicker. Development of an Anti-Biofilm Screening Technique Leads to the Discovery of a Peptoid with Efficacy against Candida albicans. ACS Infect. Dis. 2022, 8 (2), 310-320. pubmed.ncbi.nlm.nih.gov/35107257/
- R. Madison Green and Kevin L. Bicker. Discovery and Characterization of a Rapidly Fungicidal and Minimally Toxic Peptoid against Cryptococcus neoformans. ACS Med. Chem. Lett. 2021, 12 (9), 1470-1477. pubmed.ncbi.nlm.nih.gov/34531956/
- Kevin L. Bicker and Steven L. Cobb. Recent advances in the development of anti-infective peptoids. Chem. Commun. 2020, 56, 11158-11156. pubmed.ncbi.nlm.nih.gov/32870199/
- R. Madison Green and Kevin L. Bicker. Evaluation of peptoid mimics of short, lipophilic peptide antimicrobials. Int. J. Antimicrob. Agents 2020, 56 (2), 106048. https://pubmed.ncbi.nlm.nih.gov/32540430/
- Sabrina K. Spicer, Aarthi Subramani, Angelica L. Aguila, R. Madison Green, Erin E. McClelland, Kevin L. Bicker. Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5. Biopolymers 2019, 110 (6), e23276. www.ncbi.nlm.nih.gov/pubmed/30938841
- Madyson P. Middleton, Scott A. Armstrong, Kevin L. Bicker. Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification. Bioorg. Med. Chem. Lett. 2018, 28 (22), 3415-3419. www.ncbi.nlm.nih.gov/pubmed/30297282
- Carmelo Carmona-Rivera, Erica Moore, Nithya Lingampalli, Hannes Uchtenhagen, Eddie James , Kevin L. Bicker, Heidi Wahamaa, Victoria Hoffmann, Anca Catrina, Paul R.Thompson, Jane H. Buckner, William H. Robinson, David A. Fox, Mariana J. Kaplan. Arthritogenic citrullinated peptides present in neutrophil extracellular traps are internalized by synovial fibroblasts through a RAGE-TLR9 axis and activate adaptive immunity in rheumatoid arthritis. Science Immunology. 2017, 2, eaag3358. www.ncbi.nlm.nih.gov/pmc/articles/PMC5479641/
- Jeremy A. Turkett and Kevin L. Bicker. Evaluating the Effect of Peptoid Lipophilicity on Antimicrobial Potency, Cytotoxicity, and Combinatorial Library Design. ACS Combi. Sci. 2017, DOI: 10.1021/acscombsci.7b00007
- Ashley E. Corson, Scott A. Armstrong, Matthew E. Wright, Erin E. McClelland, Kevin L. Bicker. Discovery and Characterization of a Peptoid with Antifungal Activity Against Cryptococcus neoformans. ACS Med. Chem. Lett. 2016 7 (12), 1139-1144. https://www.ncbi.nlm.nih.gov/pubmed/27994753?dopt=Abstract
- Kevin J. Fisher, Jeremy A. Turkett, Ashley E. Corson, Kevin L. Bicker. Peptoid Library Agar Diffusion (PLAD) Assay for the high-throughput identification of antimicrobial peptoids. ACS Combi. Sci. 2016, 18 (6), 287-291. http://www.ncbi.nlm.nih.gov/pubmed/27186808
- Daniel M. Lewallen,† Kevin L. Bicker,† Venkataraman Subramanian,† Kathleen W. Clancy, Daniel J. Slade, Richard Brust, Julianne Martell, Christina J. Dreyton, Jeremy Sokolove, Eranthie Weerapana, and Paul R. Thompson. A chemical proteomic platform to identify citrullinated proteins. ACS Chem. Biol. 2015, 10, 2520-2538. († denotes co-first authors) http://www.ncbi.nlm.nih.gov/pubmed/26360112
- Huw D Lewis, John Liddle, Jim E Coote, Stephen J Atkinson, Michael D Barker, Benjamin D Bax, Kevin L Bicker, Ryan P Bingham, Matthew Campbell, Yu Hua Chen, Chun-wa Chung, Peter D Craggs, Rob P Davis, Dirk Eberhard, Gerard Joberty, Kenneth E Lind, Kelly Locke, Claire Maller, Kimberly Martinod, Chris Patten, Oxana Polyakova, Cecil E Rise, Martin Rüdiger, Robert J Sheppard, Daniel J Slade, Pamela Thomas, Jim Thorpe, Gang Yao, Gerard Drewes, Denisa D Wagner, Paul R Thompson, Rab K Prinjha & David M Wilson. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat. Chem. Biol. 2015, 11, 189-191. http://www.ncbi.nlm.nih.gov/pubmed/25622091
- Lewallen, Daniel M.; Bicker, Kevin L.; Madoux, Franck; Chase, Peter; Anguish, Lynne; Coonrod, Scott; Hodder, Peter; Thompson, Paul, R. A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs. ACS Chem. Biol. 2014. 9 (4), 913-921. http://www.ncbi.nlm.nih.gov/pubmed/24467619
- Bicker, Kevin L.; Thompson, Paul R. The protein arginine deiminases (PADs): Structure, Function, Inhibition, and Disease. Biopolymers, 2013, 99 (2), 155–163. http://www.ncbi.nlm.nih.gov/pubmed/23175390
- Bicker, Kevin L.; Subramanian, Venkataraman; Chumanevich, Alexander A.; Hofseth, Lorne J.; and Thompson, Paul R. Seeing citrulline: Development of a phenylglyoxal-based probe to visualize protein citrullination. J. Am. Chem. Soc., 2012, 134 (41),17015–17018. http://www.ncbi.nlm.nih.gov/pubmed/23030787
- Bicker, Kevin L.; Anguish, Lynne; Chumanevich, Alexander A.; Cameron, Michael D.; Subramanian, Venkataraman; Zhang, Xuesen; Chumanevich, Alena P.; Hofseth, Lorne J.; Coonrod, Scott A.; and Thompson, Paul R. Second generation protein arginine deiminase inhibitors based on D-amino acids: Synthesis, pharmacokinetics, and in vivo characterization. ACS Med. Chem. Lett. 2012, 3 (12), 1081–1085. http://www.ncbi.nlm.nih.gov/pubmed/23420624
- Zhang, Xuesen; Bolt, Michael; Guertin, Michael J.; Chen, Wei; Zhang, Sheng; Cherrington, Brian D.; Slade, Daniel J.; Dreyton, Christina J.; Subramanian, Venkataraman; Bicker, Kevin L.; Thompson, Paul R.; Mancini, Michael A.; Lis, John T.; Coonrod, Scott A. Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation. Proc. Nat. Acad. Sci. U.S.A. 2012, 109, (33), 13331-13336. http://www.ncbi.nlm.nih.gov/pubmed/22853951
- Bicker, Kevin L.; Sun, Jing; Harrell, Morgan; Yu Zhang; Maria M. Pena; Thompson, Paul R.; Lavigne, John J. Synthetic lectin arrays for the detection and discrimination of cancer associated glycans and cell lines. Chem. Sci. 2012, 3, 1147-1156. http://pubs.rsc.org/en/content/articlelanding/2012/sc/c2sc00790h
- Bicker, Kevin L.; Wiskur, Sheryl W.; Lavigne, John J. 2011 Colorimetric Sensor Design. Wang, Binghe; Anslyn, Eric V. Chemosensors: Principles, Strategies, and Applications. (pp. 275-296). John Wiley & Sons, Inc. USA.
- Bicker, Kevin L.; Sun, Jing; Lavigne, John J.; Thompson, Paul R. Boronic acid functionalized peptidyl synthetic lectins: Combinatorial library design, peptide sequencing, and selective glycoprotein recognition. ACS Combi. Sci. 2011, 13, 232-243. http://www.ncbi.nlm.nih.gov/pubmed/21405093
- Bicker, Kevin L.; Obianyo, Obiamaka; Rust, Heather L.; Thompson, Paul R. A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1. Mol. Biosyst. 2011, 7, 48-51. http://www.ncbi.nlm.nih.gov/pubmed/20607165
- Zou, Yuejiao; Broughton, Dana L.; Bicker, Kevin L.; Thompson, Paul R.; Lavigne, John J. Peptide borono lectins (PBLs): A new tool for glycomics and cancer diagnostics. ChemBioChem. 2007, 8(17), 2048-2051. http://www.ncbi.nlm.nih.gov/pubmed/17924602
Patents
- Bicker, Kevin L., Middleton, Madyson P., Armstrong, Scott A.; Antifungal peptoids with improved potency and selectivity towards Cryptococcus neoformans. Provision filed 2018.
- Bicker, Kevin L., Fisher, Kevin J., and Corson, Ashley E.; Peptoid Library Agar Diffusion Assay for High-Throughput Identification of Antimicrobial Compounds. Provision filed 2016. Publication Number: US20170268032A1
- Bicker, Kevin L. and Tilford, R. William. Process for Surfactant Separation and Recovery Using Reversible Binding of Boronic-Acid and Diol Compounds. 2018. Patent Number: US10155676B2
- Thompson, Paul R., Bicker, Kevin L., and Subramanian, Venkataraman. The Design, Synthesis, and Method Development of Novel Phenyl Glyoxal Probes: Tools for the Investigation of Cellular Citrullination. 2013. Patent Number: US9921225B2